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The war between humans and vampires continues, but the humans' best hope, human-vampire hybrid warrior Blade, has been framed for countless murders, turning popular sentiment against him. The vampire leader responsible for Blade's bad publicity is Danica Talos, who's determined to finally lead her bloodthirsty compatriots to victory. Now Blade must team up with a band of rogue vampire hunters to save humanity.
Starring: Wesley Snipes, Jessica Biel, Kris Kristofferson, Ryan Reynolds, Dominic Purcell, Parker Posey